Dr. Cristina Cobaleda specialist in aesthetic medicine
Aesthetic physician
Medical license no. 51612
Leading doctor in expression wrinkle treatment
The doctor sees patients in BarcelonaView medical profile
Expression wrinkle treatment
Thinking about having treatment for expression wrinkles?
It temporarily relaxes the muscles that create expression wrinkles, the ones that appear with facial movement on the forehead, between the eyebrows and around the eyes (crow's feet).
From: 390 €
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Treatment duration:
30-45 minutes
With NESAI® Derm ultrasound
Included in Barcelona (subject to the doctor's assessment)
Duration:
4 to 6 months
Visible result:
From 3-5 days onward
Final result:
Between 2 and 3 weeks
What is expression wrinkle treatment?
The anti-wrinkle treatment at Instituto de Benito is an aesthetic medicine procedure based on a medical treatment that temporarily relaxes the muscles responsible for dynamic expression wrinkles (the ones that appear with facial movement) on the forehead, between the eyebrows and around the eyes (crow's feet). It is one of the most requested treatments in aesthetic medicine because it is quick, well tolerated and gives a natural-looking result when performed by an experienced doctor.
Which areas can we treat?
Upper third: forehead
Horizontal forehead lines appear when you raise your eyebrows. Botulinum toxin helps soften these lines while keeping your expression natural and avoiding a stiff look.
Frown lines (glabella)
This is one of the most frequently treated areas. The vertical lines that form when you frown can make you look angry or tired. The treatment relaxes these muscles and softens your expression, for a more rested-looking face.
Crow's feet (eye contour)
These wrinkles appear when you smile or make facial expressions. Botulinum toxin reduces them without losing the expressiveness of your eyes, for a fresher look.
Lower third (advanced treatment)
This includes areas such as the barcode lines (upper lip), the corners of the mouth and the chin. Here the application is more precise and personalized, as the aim is to balance your expression without affecting function, improving the overall appearance of the face.
Patients who have trusted Instituto de Benito look like this:
@laadanez
What does treatment to remove expression wrinkles involve?
The treatment is carried out entirely in a medical office at Instituto de Benito in Barcelona or Madrid, in an outpatient session that is always planned and performed by a licensed aesthetic doctor. It consists of the following steps:
Personalized medical assessment
Before the treatment, you have a consultation with the aesthetic doctor at Instituto de Benito, who studies your case, listens to your goals, rules out contraindications and designs a personalized plan. The first aesthetic medicine consultation costs €50 (deductible from your first treatment).
Skin ultrasound with NESAI
When the doctor considers it necessary, a NESAI Derm ultrasound is performed in Barcelona to assess the skin before treating: dermis thickness, density, collagen, fibers and sun damage.
Preparing for the treatment
Preparation is simple: the area should be clean and free of creams. Your doctor will tell you whether you should avoid any medication in the days beforehand to minimize bruising, and will discuss with you anything relevant to your safety.
Treatment application in the clinic
The doctor disinfects the area, applies topical anesthesia if necessary and performs the microinjections with very fine needles, following the plan designed. The session is carried out entirely in the doctor's office and the patient returns to their routine immediately.
Start seeing yourself the way you want to feel
Results appear within the timeframe expected for the treatment, with a natural, harmonious finish. The doctor gives you home care instructions and schedules your follow-up appointments.
Before and after care for anti-wrinkle treatment
How much does anti-wrinkle treatment for expression wrinkles cost
Standard treatment €390 · Touch-up treatment €275. The final price depends on the area or areas to be treated, the product or cocktail used and the number of sessions your doctor recommends after the consultation. The first aesthetic medicine consultation costs €50 (deductible from your first treatment). We offer financing for longer treatments and treatment packages.
Are you a good candidate for anti-wrinkle treatment?
Anti-wrinkle treatment is suitable for people in good general health who match any of these profiles. Final suitability is confirmed by the doctor after a personalized consultation.
- 01
Visible expression lines
Lines between the eyebrows, on the forehead or around the eyes that appear with facial movement and are starting to show at rest.
- 02
Preventive treatment in younger patients
From the age of 28-30, low-dose sessions to prevent deep dynamic wrinkles from forming.
- 03
Mild asymmetries of expression
When one eyebrow sits higher than the other or there is facial asymmetry with movement.
- 04
Bruxism treatment
Application in the masseter muscles to reduce chewing force and relieve bruxism.
- 05
Hyperhidrosis (excessive sweating)
A specific indication with different dosing for the underarms, hands, feet or forehead.
- 06
Gummy smile
Application in the muscles that lift the upper lip to reduce excessive gum exposure.
Before and after photos of expression wrinkles
Sheila Martori, patient from Madrid
Softening expression lines with aesthetic medicine ✨
Miguel, patient from Barcelona
Softening crow's feet wrinkles with aesthetic medicine ✨
Sara, patient from Barcelona
Softening expression lines with aesthetic medicine ✨
Sheila Martori, patient from Madrid
Softening crow's feet with aesthetic medicine ✨
Lucre, patient from Barcelona
Removing forehead wrinkles with aesthetic medicine ✨
Sheila Martori, patient from Madrid
Softening expression lines with aesthetic medicine ✨
Who is not a candidate: contraindications for anti-wrinkle treatment
Patient safety comes before any aesthetic result. Anti-wrinkle treatment should not be performed, or should be postponed, in the following cases:
| Contraindication | Reason |
|---|---|
| Pregnancy and breastfeeding | Injectable treatments are not performed during pregnancy or breastfeeding. |
| Active infection or lesion in the area | Herpes, folliculitis, dermatitis or open wounds: treatment is postponed until they have resolved. |
| Autoimmune disease or immunosuppression in an active phase | Requires individual assessment and, in some cases, a report from the specialist managing the case. |
| Anticoagulant treatment or a clotting disorder | Increases the risk of bruising; it is assessed with the prescribing doctor. |
| Known allergy to any of the components | Contraindicates the treatment. |
| Neuromuscular disease | Myasthenia gravis and similar conditions are a contraindication for botulinum toxin. |
| Treatment with aminoglycosides | They can increase the effect of the toxin; the timing of the treatment is assessed. |
Risks and possible side effects of anti-wrinkle treatment
Anti-wrinkle treatment is safe when performed by a licensed doctor in an authorized center using approved medical products. Even so, every medical procedure has a profile of possible effects that it is only honest to share with you.
Expected, mild reactions
- Redness and slight swelling at the injection points.
- Small bruises, which resolve within a few days.
- Tenderness or mild discomfort in the treated area.
Less common effects
- Temporary asymmetry between the two sides, which can be corrected at the follow-up visit.
- Temporary drooping of the eyelid or eyebrow, which resolves on its own.
- Mild headache in the first few days.
Our aesthetic medicine medical team
The team tailors each treatment to the patient, with the aim of a natural result.
Maria Elechiguerra, aesthetic medicine specialist
Aesthetic medicine specialist in Madrid
View medical profile
Commitment to facial aesthetic medicine
Anti-wrinkle treatment is one of the most prescribed procedures at Instituto de Benito, and we apply a strict protocol for dosing, dilution and batch traceability in every session, without exception.
At Instituto de Benito, patient safety comes before any aesthetic goal. We work with audited clinical protocols, medical products with medical CE marking and batch traceability, single-use instruments, dedicated aesthetic medicine rooms and personalized follow-up between sessions. We never delegate a medical-aesthetic procedure to non-medical staff.
Evidence and medical backing
The product used in anti-wrinkle treatment is authorized by the Spanish Agency of Medicines and Medical Devices (AEMPS) and by the European Medicines Agency (EMA) for aesthetic use in adults, with decades of accumulated clinical evidence. The Spanish Society of Aesthetic Medicine (SEME) lists it among the most studied facial aesthetic medicine treatments and sets out specific guidelines on dosing, technique and informed consent, which we follow in every session. It is only administered on prescription and applied directly by a doctor.
Where to have wrinkle removal treatment?
Related treatments
Frequently asked questions about removing expression wrinkles
How long does anti-wrinkle treatment last?
The effect of anti-wrinkle treatment lasts between 4 and 6 months. To maintain the result, we recommend repeating the session every 4-6 months.
When are the results visible?
The first effects are visible after 3-7 days, with the optimal result 14 days after the session.
Does anti-wrinkle treatment leave your face expressionless?
No. When performed by an experienced aesthetic doctor, anti-wrinkle treatment softens expression wrinkles while preserving the natural movement of your face.
How much does anti-wrinkle treatment cost at Instituto de Benito?
The standard treatment costs €390. The touch-up option costs €275. Centers in Barcelona and Madrid.
Does anti-wrinkle treatment leave your face expressionless?
No. When performed by an experienced aesthetic doctor, the treatment softens expression wrinkles while preserving the natural movement of your face.
When can I exercise after anti-wrinkle treatment?
For the first 4 hours we recommend not bending over or doing intense exercise, to prevent the product from spreading. After that you can go back to your routine.
Does the effect wear off suddenly?
No. The effect fades gradually between the 4th and 6th month. The skin returns to its natural state with no rebound effect.
What is the difference between anti-wrinkle treatment and hyaluronic acid filler?
Anti-wrinkle treatment temporarily relaxes the muscles responsible for dynamic wrinkles (the ones that appear with facial movement). Hyaluronic acid filler adds volume and fills static or structural wrinkles. They are complementary: many patients combine the two. Anti-wrinkle treatment works on the forehead, between the eyebrows and on crow's feet; hyaluronic acid on folds, under-eye circles, lips, cheekbones
What percentage of patients does anti-wrinkle treatment work for?
According to the scientific literature compiled by the SEME, more than 95% of patients see a clear improvement in dynamic wrinkles 14 days after treatment. A small proportion (≈1-3%) are less sensitive to the product because they develop antibodies; in those cases the doctor adjusts the regimen.
How is the right dose chosen for me?
The doctor assesses your natural facial movement during the consultation (you will be asked to raise your eyebrows, frown and smile) and decides the injection points and the dose based on the strength of your muscles, the depth of your wrinkles and your aesthetic goal: a subtle preventive effect, moderate softening or a more marked result.
What if I have an important event in a few days?
The optimal result appears after 14 days. If you have a wedding, a professional event or a photo shoot, plan your session 2-3 weeks in advance so that the initial swelling (minimal, lasting hours) has already passed and the effect has settled.
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